Resuscitation &
Translational Bioenergetics
Laboratory

Resuscitation &
Translational Bioenergetics
Laboratory

Resuscitation Biology · Mitochondrial Medicine · Translational Therapeutics

We study the mechanisms of injury and recovery after cardiac arrest and acute critical illness, translating discoveries in mitochondrial biology, redox signaling, and resuscitation science into new therapeutic strategies.

Kei Hayashida, MD, PhD, FAHA — Emergency Physician | Physician-Scientist
Northwell Health | The Feinstein Institutes for Medical Research

OUR MISSION

From mechanism to resuscitation to recovery.

Our laboratory investigates the biological mechanisms that determine injury and recovery after cardiac arrest and global ischemia-reperfusion. We integrate mitochondrial and redox biology, clinically relevant experimental models, physiological monitoring, human biospecimens, and clinical data to develop new strategies for resuscitation and post-cardiac arrest care.

RESEARCH PROGRAMS

Research focus

01

Cardiac Arrest & Resuscitation Science — We investigate the mechanisms, physiology, and clinical determinants of injury and recovery following cardiac arrest and resuscitation, including neurological, cardiovascular, and multi-organ outcomes.

02

Mitochondrial & Bioenergetic Medicine — We study mitochondrial dysfunction, cellular bioenergetics, intercellular mitochondrial transfer, and mitochondria transplantation as therapeutic strategies for ischemia-reperfusion injury.

03

Ischemia-Reperfusion & Redox Biology — We investigate oxidative stress, cytokine response, metabolic disruption, and medical gas biology as mechanisms and therapeutic targets following global ischemia-reperfusion.

04

Translational Therapeutics — We develop therapeutic concepts across mechanistic studies, cellular systems, small- and large-animal models, and clinical translation, with a focus on neuroprotection, cardiovascular recovery, and multi-organ recovery after acute critical illness.

05

Clinical Emergency & Resuscitation Research — We integrate physiological monitoring, biomarkers, clinical biospecimens, and real-world emergency care to identify clinically actionable predictors and therapeutic opportunities.

SCIENTIFIC VISUAL STORY

Mechanism → Physiology → Translation → Patient

From molecule to patient.

CELLULAR

Mitochondrial and molecular biology

PHYSIOLOGY

Perfusion, bioenergetics, and organ function

TRANSLATION

Clinically relevant experimental models

CLINICAL research

TRANSLATIONAL PIPELINE

A translational research continuum

01

Mechanistic Discovery

02

Small-Animal Models

03

Large-Animal Models

04

Human Biospecimens & Clinical Data

05

First-in-Human / Clinical Translation

SCIENTIFIC CONTRIBUTIONS

Scientific Contributions

01

Mitochondria Transplantation

02

Medical Gas Biology & Neuroprotection

03

Clinical Translation

04

Mechanisms of Multi-Organ Injury After Cardiac Arrest

CLINICAL TRANSLATION

Discovery is most meaningful when it can change patient care.

“The laboratory combines mechanistic experimentation with clinically relevant models and human research to shorten the distance between biological discovery and resuscitation care.”

“The laboratory combines mechanistic experimentation with clinically relevant models and human research to shorten the distance between biological discovery and resuscitation care.”

SELECTED PUBLICATIONS

Publications

OUR TEAM

Clinicians and scientists working across disciplines.

“Clinicians, scientists, trainees, and collaborators working across resuscitation science, mitochondrial biology, physiology, and translational medicine.”

“Clinicians, scientists, trainees, and collaborators working across resuscitation science, mitochondrial biology, physiology, and translational medicine.”

View Team (Coming Soon) →

COLLABORATIVE SCIENCE

Science across disciplines and borders.

“We collaborate with investigators in emergency medicine, critical care, cardiovascular science, mitochondrial biology, veterinary medicine, engineering, and data science in the United States, Japan, and internationally.”

“We collaborate with investigators in emergency medicine, critical care, cardiovascular science, mitochondrial biology, veterinary medicine, engineering, and data science in the United States, Japan, and internationally.”

EXTERNAL ACTIVITIES

External Scientific & Medical Advisory

“Selected external scientific and medical advisory activities are provided independently by Kei Hayashida, MD, PhD, FAHA.”

“Selected external scientific and medical advisory activities are provided independently by Kei Hayashida, MD, PhD, FAHA.”

Resuscitation & Translational Bioenergetics Laboratory

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